Guitarist, singer, and songwriter Duwayne Burnside is one of 14 children born to legendary North Mississippi musician R.L. Burnside and his wife, Alice. He has been a frequent performer with the North Mississippi Allstars since the early 1990s, when that group, fronted by Luther and Cody Dickinson, formed. The young Burnside learned his first few guitar licks and chords from his father, but proved a quick study and soon began playing with local club owner Junior Kimbrough and the Soul Blues Boys. Growing up in Holly Springs, he was close to Memphis, and as soon as he was able to get to Memphis, he did, and soon had the chance to sit in with Little Jimmy King, Albert King, B.B. King, Bobby "Blue" Bland, and others. Duwayne also began playing in his Dad's band, Sound Machine Groove, where he further honed his skills as a guitarist and showman. He recorded for Hightone and Fat Possum Records with his father's group before moving to Memphis, where he opened his own club, Burnside Kitchen and Grill, near Highway 61. He booked the music, cooked the food, sold the beer, and had his own band perform there on a weekly basis.